Atrial Fibrillation Is Associated With Increased Spontaneous Calcium Release From the Sarcoplasmic Reticulum in Human Atrial Myocytes
Key result
Atrial fibrillation was associated with a higher frequency of spontaneous Ca2+ sparks (6.0 vs 2.8 sparks/mm per second, P<0.05) and Ca2+ waves compared to patients without the arrhythmia.
Authors
Discussion
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Implication
Spontaneous SR Ca2+ release observed in human AF myocytes; leaves open its causal role in arrhythmia initiation.
Study Design
Type
Observational
PICO
P
Population
Patients with and without atrial fibrillation whose isolated atrial myocytes were analyzed for spontaneous calcium release.
E
Exposure / Comparator
Atrial fibrillation vs Patients without atrial fibrillation
O
Primary Outcome
Ca2+ spark frequency (sparks/mm per second), p=<0.05
Main Result
Absolute Event Rate: 6% vs 2.8%
p-value: p=<0.05
Cite This Study
Hove‐Madsen et al. (2004) conducted an observational in Atrial fibrillation. Atrial fibrillation vs. Patients without atrial fibrillation was evaluated on Ca2+ spark frequency (sparks/mm per second) (p=<0.05). Atrial fibrillation was associated with a higher frequency of spontaneous Ca2+ sparks (6.0 vs 2.8 sparks/mm per second, P<0.05) and Ca2+ waves compared to patients without the arrhythmia.