Key result
Type 2 diabetes mellitus was associated with significantly increased Endothelin (ET-1) and uric acid levels compared to controls, with ET-1 positively correlated with uric acid (p < 0.05).
Why the study?
The study aimed to evaluate the direct link between uric acid rates and endothelin (ET-1), an indicator of endothelial dysfunction or damage, in patients with T2-DM.
Is there a correlation between uric acid levels and Endothelin (ET-1) in patients with Type 2 Diabetes Mellitus?
Case-Control (n=192)
Is there a correlation between uric acid levels and Endothelin (ET-1) in patients with Type 2 Diabetes Mellitus?
p-value: p=< 0.05
Elevated uric acid levels in patients with Type 2 Diabetes Mellitus correlate significantly with increased Endothelin-1, suggesting a potential pathway for endothelial dysfunction and cardiovascular disease development.
This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.
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Ismail et al. (2020) conducted a case-control in Type 2 Diabetes Mellitus (n=192). Type 2 Diabetes Mellitus vs. Controls was evaluated on Endothelin (ET-1) levels and correlation with uric acid, urea, and blood pressure (p=< 0.05). Type 2 diabetes mellitus was associated with significantly increased Endothelin (ET-1) and uric acid levels compared to controls, with ET-1 positively correlated with uric acid (p < 0.05).
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