Key result
IL-1beta stimulation of human umbilical vein endothelial cells increased PGH2 release, correlating with COX-2 expression and PGIS inactivation likely involving NO and HO radicals.
Population
Human umbilical vein endothelial cells (HUVECs)
Comparison
Interleukin-1beta stimulation, exogenous labeled… vs Resting HUVECs
Design
Preclinical
Authors
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Transient PGI2 release after IL-1β in HUVECs; leaves open its role in vascular inflammation.
IL-1beta induces HUVECs to release PGH2, which isomerizes into vasoconstrictor prostanoids, a process dependent on COX-2 expression and PGIS inactivation by reactive nitrogen and oxygen species.
Camacho et al. (1998) studied this question. Interleukin-1beta (IL-1beta) vs. Resting cells was evaluated on Biosynthesis of vasoconstrictor prostanoids. IL-1beta stimulation of human umbilical vein endothelial cells increased PGH2 release, correlating with COX-2 expression and PGIS inactivation likely involving NO and HO radicals.
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