Population
Cultured human umbilical vein endothelial cells (HUVEC)
Comparison
Pretreatment with cytokines followed by… vs Untreated HUVEC stimulated with thrombin, or…
Design
Preclinical
Authors
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IL-1β may prime endothelial PGI2 responses in inflammation; hypothesis-generating for cytokine-vascular interactions, requires in vivo confirmation.
IL-1 and related cytokines selectively prime endothelial cells for enhanced PGI2 production in response to thrombin and histamine, likely through induction of biosynthetic enzymes.
Zavoico et al. (1989) studied this question.
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