Manifestations of excessive and systemic reactogenicity of vaccine, requirements for vaccination against new coronavirus infection

Introduction. The new coronavirus infection (COVID-19) has led not only to a pandemic accompanied by high mortality, a great demand for the use of various drugs, but also to an unprecedented rapid development. In order to reduce the rate of infection spread and the severity of the course of the disease, COVID-19 vaccines were approved for practical use in a number of countries in 2021. Vaccines against SARS-CoV-2 have been proven to be safe and effective against this infection. However, with all types of vaccines, various side and unwanted effects may occur. Reactions to COVID-19 vaccination are usually mild to moderate and are usually short-lived. Objective. To characterize the main adverse and adverse effects reported within 20 months of WHO approval of SARS-CoV-2 vaccination. Materials and methods. Literature was analyzed from various databases, including PubMed, WHO. The key terms used in the literature search were: coronavirus, SARS-CoV-2, COVID-19 pandemic, vaccines, vaccine, and adverse and adverse effects. The review includes 38 sources, including research articles, clinical trials, and literature reviews. Conclusions. The results of the presented review can be used as an additional tool in planning comparative studies of the efficacy and safety of vaccine prevention against COVID-19.