Key result
The renal afferent arteriole can sense and rapidly adjust tone in response to changes in systolic pressure presented at the heart rate, protecting the glomerulus from hypertensive injury.
Population
Renal afferent arteriole (rat model discussed)
Design
Review
Authors
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Myogenic afferent arteriolar vasoconstriction protects glomeruli from hypertension; leaves open targeted modulation in hypertensive kidney disease.
The renal afferent arteriole protects the glomerulus from systolic blood pressure elevations through rapid myogenic vasoconstriction, challenging the view that the renal vasculature responds passively to high-frequency pressure signals.
Loutzenhiser et al. (2004) conducted a review in Hypertension and kidney disease. Elevated systolic blood pressure was evaluated on Myogenic response of the renal afferent arteriole. The renal afferent arteriole can sense and rapidly adjust tone in response to changes in systolic pressure presented at the heart rate, protecting the glomerulus from hypertensive injury.
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