Key result
Acute and chronic increases in arterial pressure provoked the redistribution of apical NHE3 from the brush border to the base of microvilli in the proximal tubules of rats.
Why the study?
Does acute and chronic hypertension induce redistribution of NHE3 in proximal tubules in rat models?
Population
Sprague-Dawley rats, spontaneously hypertensive rats, and two-kidney, one-clip Goldblatt hypertensive rats
Comparison
Acute hypertension and chronic hypertension vs Normotensive state
Design
Preclinical
Authors
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Hypothesis-generating for NHE3 redistribution in pressure natriuresis; leaves open human relevance and clinical translation.
Does acute and chronic hypertension induce redistribution of NHE3 in proximal tubules in rat models?
Both acute and chronic increases in arterial pressure provoke the redistribution of apical NHE3 in proximal tubules, suggesting it is an integral part of pressure natriuresis.
Yip et al. (1998) studied Hypertension. Acute and chronic hypertension vs. Normotensive state or non-exposed kidneys was evaluated on Redistribution of NHE3 in proximal tubules. Acute and chronic increases in arterial pressure provoked the redistribution of apical NHE3 from the brush border to the base of microvilli in the proximal tubules of rats.
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