Key result
NHE3-mediated proximal tubular bicarbonate reabsorption was reduced with age in spontaneously hypertensive rats (1.08 vs. 0.41 nmol/cm2×s), adapting to hypertension via NHE3 redistribution.
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Hypothesis-generating for age-related NHE3 adaptation in hypertensive models; human studies needed before clinical relevance.
Absolute Event Rate: 0.41% vs 1.08%
Crajoinas et al. (2010) studied Hypertension. Development of hypertension (transition from youth to adulthood) vs. Age-matched Wistar Kyoto (WKY) rats was evaluated on NHE3-mediated PT bicarbonate reabsorption. NHE3-mediated proximal tubular bicarbonate reabsorption was reduced with age in spontaneously hypertensive rats (1.08 vs. 0.41 nmol/cm2×s), adapting to hypertension via NHE3 redistribution.
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