Key result
NHERF1 mRNA expression was significantly decreased in both prehypertensive and hypertensive SHR compared with WKY rats, whereas NHERF2 mRNA expression was significantly increased only in the hypertensive period.
Population
Prehypertensive 4-week-old and hypertensive 11-week-old spontaneously hypertensive rats, age-matched…
Comparison
Antihypertensive treatment and high-salt diet vs Age-matched WKY rats; normotensive DS rats fed a…
Design
Preclinical
Authors
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NHERF1/2 shifts in SHR should not change practice; hypothesis-generating for isoform roles in hypertensive NHE regulation.
Decreased expression of NHERF1 may be genetically determined and related to enhanced NHE activity in spontaneously hypertensive rats, while increased NHERF2 expression may act as a compensatory mechanism.
Kobayashi et al. (2004) studied Hypertension. Genetic hypertension (Spontaneously hypertensive rats) vs. Age-matched Wistar-Kyoto (WKY) rats was evaluated on mRNA expression of NHERF1 and NHERF2 in the kidney and NHE activity. NHERF1 mRNA expression was significantly decreased in both prehypertensive and hypertensive SHR compared with WKY rats, whereas NHERF2 mRNA expression was significantly increased only in the hypertensive period.
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