Renal denervation alters the expression of sodium-hydrogen exchangers and their regulatory proteins in the kidneys of spontaneously hypertensive rats, suggesting a mechanism by which the sympathetic nervous system regulates renal sodium handling.
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Animal data on NHE/NHERF after renal denervation in SHR warrant caution; leaves open relevance to human hypertension therapy.
Li et al. (2018) studied this question.
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