Key result
In young prehypertensive SHR, the Na+-H+ exchange recovery rate in S1 was significantly higher than in WKY rats, while adult SHR showed markedly low NEM-sensitive H+ efflux in S2.
Population
Isolated single proximal tubules from young prehypertensive and adult spontaneously hypertensive rats and…
Comparison
Assessment of Na-independent H+ efflux and Na-H+… vs Normotensive Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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Altered Na+-H+ exchange in prehypertensive SHR may contribute to hypertension pathogenesis; leaves open human relevance and should not change practice.
Spontaneously hypertensive rats exhibit altered Na(+)-H+ exchange and impaired maturation of H+ pump activity in proximal tubules, which may contribute to the pathogenesis of hypertension.
Dagher et al. (1992) studied Hypertension. Spontaneously hypertensive rat (SHR) strain vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Na-independent NEM-sensitive H+ efflux and Na-dependent H+ efflux (recovery rate of intracellular pH). In young prehypertensive SHR, the Na+-H+ exchange recovery rate in S1 was significantly higher than in WKY rats, while adult SHR showed markedly low NEM-sensitive H+ efflux in S2.
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