Why the study?
Does enalaprilat affect proximal tubular fluid reabsorption differently across ages in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
Population
Spontaneously hypertensive rats (SHR) at 5, 7 and 12 weeks of age and age-matched Wistar-Kyoto rats (WKY)
Comparison
Enalaprilat vs Baseline and age-matched WKY rats
Design
Preclinical
Authors
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May indicate age-dependent loss of Ang II tubular effects in hypertensive rats; leaves open relevance to early sodium retention in human hypertension.
Does enalaprilat affect proximal tubular fluid reabsorption differently across ages in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
Age-related changes in proximal tubular reabsorption and loss of Ang II stimulation by 12 weeks may contribute to early sodium retention in spontaneously hypertensive rats.
Thomas et al. (1988) studied this question.
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