January 1, 1998Hypertension

Response of Proximal Tubules to Angiotensin II Changes During Maturation

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Population

Rats from three age groups: young (4 to 5 weeks old), intermediate (6 weeks old), and adult (7 weeks old).

Comparison

Angiotensin II vs Baseline measurements and comparison across age…

Design

Preclinical

Authors

JGJeffrey L. GarvinUniversity School WBWilliam H. BeierwaltesVascular / Pulmonary Vascular

Discussion

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Implication

Caution extrapolating adult Ang II data to youth; leaves open age-specific tubular mechanisms in human hypertension.

Structured PICO

Population

Rats from three age groups: young (4 to 5 weeks old), intermediate (6 weeks old), and adult (7 weeks old).

Intervention

Angiotensin II (10^-10 mol/L for in vitro tubular studies; graded doses of 8, 40, and 200 fmol/g body weight for in vivo hemodynamics)

Comparator

Baseline measurements (pre-Angiotensin II) and comparison across age groups (young vs. intermediate vs. adult)

Outcome

Proximal nephron volume absorption (Jv), tubular cAMP content, blood pressure (BP), renal blood flow (RBF), and renal vascular resistance (RVR)surrogate

During adolescent development in rats, Angiotensin II exerts a greater effect on proximal tubular salt and water absorption compared to adults, mediated by cAMP, without differences in renal hemodynamics.

Cite This Study

Garvin et al. (1998) studied this question.

synapsesocial.com/papers/6a8d0e52851ec846c20e55bf https://doi.org/10.1161/01.hyp.31.1.415

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Response of Proximal Tubules to Angiotensin II Changes During Maturation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Response of Proximal Tubules to Angiotensin II Changes During Maturation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider