May 1, 1990Journal of Hypertension

Altered responsiveness of proximal tubule fluid reabsorption of peritubular angiotensin II in spontaneously hypertensive rats

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Population

5- and 12-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY)

Comparison

Peritubular angiotensin II administered via… vs Age-matched normotensive Wistar-Kyoto rats (WKY)

Design

Preclinical

Authors

DTDavid M. ThomasNew South Wales Department of Health PHP. HarrisNational Physical Laboratory TMTrefor MorganUniversity of Mississippi Medical Center

Discussion

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Implication

Altered Ang II sensitivity in young SHR may inform hypertension mechanisms; leaves open human translation and clinical relevance.

Structured PICO

Population

5- and 12-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY)

Intervention

Peritubular angiotensin II (Ang II) administered via split-drop micropuncture

Comparator

Age-matched normotensive Wistar-Kyoto rats (WKY)

Outcome

Stimulation of proximal tubular fluid reabsorption (dose-response relationship)surrogate

Alterations in proximal tubule responsiveness to Angiotensin II in young spontaneously hypertensive rats may contribute to sodium retention during hypertension development.

Cite This Study

Thomas et al. (1990) studied this question.

synapsesocial.com/papers/6a857cc7581d4f62e2d5a455 https://doi.org/10.1097/00004872-199005000-00002

Topics

Hypertension management

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Altered responsiveness of proximal tubule fluid reabsorption of peritubular angiotensin II in spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Altered responsiveness of proximal tubule fluid reabsorption of peritubular angiotensin II in spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider