Key result
Spontaneously hypertensive rats show reduced blood pressure responsiveness to angiotensin II versus Wistar-Kyoto rats.
Why the study?
The study aimed to investigate blood pressure responsiveness to noradrenaline and angiotensin II during the development of hypertension in conscious spontaneously hypertensive rats compared with controls.
Population
Conscious, freely moving, age-matched SHR and WKY rats from 4 to 16 weeks of age
Comparison
SHR versus WKY rats in response to intravenous noradrenaline and angiotensin II
Design
Preclinical experimental study
Follow-up
From 4 to 16 weeks of age
Authors
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Should not yet change clinical hypertension management; hypothesis-generating for age-dependent vascular reactivity in SHR models.
p-value: p=<0.05
The development of hypertension in spontaneously hypertensive rats is not driven by increased blood pressure responsiveness to circulating pressor agents like noradrenaline or angiotensin II.
Toal et al. (1985) studied Hypertension. Intravenous noradrenaline and angiotensin II vs. Wistar-Kyoto (WKY) rats was evaluated on Blood pressure responsiveness (p=<0.05). Blood pressure responsiveness to angiotensin II was significantly decreased in spontaneously hypertensive rats compared with Wistar-Kyoto rats at 12 and 16 weeks of age (p<0.05).
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