Key result
Hypertension was associated with elevated circulating endothelial microvesicles (157 vs 96 EMVs/μL; P<0.05) and reduced endothelium-dependent vasodilation.
Why the study?
To determine whether circulating endothelial microvesicles are elevated in hypertensive adults and associated with hypertension-related endothelial vasodilator dysfunction.
Are circulating endothelial microvesicles elevated in hypertensive adults and associated with endothelial vasodilator dysfunction?
Cross-Sectional (n=30)
Are circulating endothelial microvesicles elevated in hypertensive adults and associated with endothelial vasodilator dysfunction?
Absolute Event Rate: 157% vs 96%
p-value: p=<0.05
Elevated circulating endothelial microvesicles in hypertensive adults are inversely associated with vasodilation, suggesting they may serve as a biomarker for blood pressure-related endothelial dysfunction.
EMV elevation may mark endothelial dysfunction in hypertension; leaves open biomarker utility pending prospective validation.
The purpose of this study was to determine (1) if circulating endothelial microvesicles (EMVs) are elevated in hypertensive adults and (2) whether circulating EMVs are associated with hypertension-related endothelial vasodilator dysfunction. Circulating EMVs (CD31 + /42b – ) were determined in 30 middle-aged adults (55 ± 1 years): 15 normotensive (10 males, 5 females; blood pressure 114/71 ± 2/1 mm Hg) and 15 hypertensive (10 males, 5 females; blood pressure 142/87 ± 2/2 mm Hg). Forearm blood flow (FBF) (via plethysmography) was assessed by intra-arterial infusion of acetylcholine and sodium nitroprusside. Circulating EMVs were ∼65% higher (P < 0.05) in hypertensive (157 ± 10 EMVs/μL) than in normotensive (96 ± 10 EMVs/μL) adults. FBF to acetylcholine was significantly lower (∼30%) in the hypertensive group (from 5.0 ± 0.4 to 11.8 ± 0.8 mL·100 mL tissue –1 ·min –1 versus from 4.4 ± 0.2 to 15.6 ± 0.8 mL·100 mL tissue –1 ·min –1 ). Circulating EMVs were inversely associated with vasodilation (r = –0.65; P < 0.05). Hypertension is associated with elevated circulating levels of EMVs. EMVs may serve as a biomarker of, and contribute to, blood pressure related endothelial dysfunction.
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Stockelman et al. (2020) conducted a cross-sectional in Hypertension (n=30). Hypertension vs. Normotension was evaluated on Circulating endothelial microvesicles (EMVs) (p=<0.05). Hypertension was associated with elevated circulating endothelial microvesicles (157 vs 96 EMVs/μL; P<0.05) and reduced endothelium-dependent vasodilation.
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