July 24, 2019American Journal of HypertensionOpen Access

Endothelial Microvesicles Circulating in Peripheral and Coronary Circulation Are Associated With Central Blood Pressure in Coronary Artery Disease

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Why the study?

Little was known about endothelial microvesicle levels in the coronary circulation of patients with acute coronary syndrome and stable coronary artery disease.

Are endothelial microvesicles (EMVs) elevated in the coronary and peripheral circulation of patients with ACS compared to stable CAD, and are they associated with central blood pressure?

Population

Consecutive eligible patients undergoing coronary angiography

Comparison

ACS vs stable CAD vs controls, and coronary vs peripheral circulation

Design

Observational cross-sectional study

Authors

ΕGΕugenia GkaliagkousiVascular Medicine EGEleni GavriilakiAristotle University of Thessaloniki IVI. VasileiadisG. Papanikolaou General Hospital

Discussion

Member takes

Implication

EMVs may mark acute endothelial injury in ACS; leaves open their biomarker utility pending prospective studies.

Structured PICO

Are endothelial microvesicles (EMVs) elevated in the coronary and peripheral circulation of patients with ACS compared to stable CAD, and are they associated with central blood pressure?

Population

Consecutive eligible patients undergoing coronary angiography, including those with acute coronary syndrome (ACS) and stable coronary artery disease (CAD), and controls.

Intervention

Measurement of endothelial microvesicles (EMVs) from blood samples collected from the stem of the left coronary artery and the femoral artery, along with invasive measurement of central systolic blood pressure (cSBP).

Comparator

Controls (compared to CAD patients); stable CAD patients (compared to ACS patients); peripheral circulation (compared to coronary circulation).

Outcome

Levels of endothelial microvesicles (EMVs) in peripheral and coronary circulation, and their association with central systolic blood pressure (cSBP).surrogate

Endothelial microvesicles are elevated in the coronary circulation of patients with ACS and stable CAD and correlate with central blood pressure, suggesting they are markers of ongoing vascular damage.

Cite This Study

Gkaliagkousi et al. (2019) studied this question.

synapsesocial.com/papers/6a735dbb3daf6e9254b87463 https://doi.org/10.1093/ajh/hpz116

Topics

Coronary artery disease STEMI management

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