Population
Two-dimensional anisotropic cardiac propagation modeled using a finite element method
Comparison
Muscle fiber curvature vs Uniform fiber orientation
Design
Preclinical
Key result
In a computational model, muscle fiber curvature caused spiral wave drift and altered planar wavefront propagation, increasing maximal upstroke rate by 74% with a 15 degree/cm gradient.
Authors
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Computational models of fiber curvature may guide arrhythmia simulations; leaves open relevance to clinical reentry mechanisms.
Computational modeling demonstrates that muscle fiber curvature causes spiral wave drift and alters planar wave propagation, potentially impacting the stability of reentrant arrhythmias.
Rogers et al. (1994) studied Reentrant tachyarrhythmias. Muscle fiber curvature vs. Uniform fiber orientation was evaluated on Spiral wave drift and propagation parameters. In a computational model, muscle fiber curvature caused spiral wave drift and altered planar wavefront propagation, increasing maximal upstroke rate by 74% with a 15 degree/cm gradient.