Key result
Application of 4-aminopyridine induced a distinct delayed depolarization in cutaneous afferents, which had a considerably longer recovery time (99.0 +/- 28.3 ms) than the action potential.
Population
5- to 7-wk-old rats
Comparison
4-aminopyridine, tetraethylammonium, and… vs Untreated nerves or different nerve types
Design
Preclinical
Authors
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May guide axonal K+ channel studies in mixed nerves; leaves open translation to human neuropathies.
Cutaneous afferent neurons exhibit distinct electrophysiological properties, including delayed depolarization and slow sodium currents, compared to muscle afferents.
Honmou et al. (1994) studied this question. 4-aminopyridine (4-AP) was evaluated on Delayed depolarization and action potential recovery time. Application of 4-aminopyridine induced a distinct delayed depolarization in cutaneous afferents, which had a considerably longer recovery time (99.0 +/- 28.3 ms) than the action potential.
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