The blocking action of 4-aminopyridine on the transient K+ current in rat sensory neurons is use-dependent and can be attenuated by membrane depolarization.
Cautions against extrapolating rat neuron findings to patients; leaves open translational studies on 4-AP block.
Effects of 4-aminopyridine (4-AP) on the transient K(+) current (I(A)) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of I(A) was reduced by 4-AP. The steady-state inactivation curve for I(A) was shifted in the positive direction by 4-AP, suggesting that the blocking action of 4-AP may be attenuated by membrane depolarization. When two I(A)s were evoked with variable intervals, the peak amplitude of the I(A) induced by the second pulse was augmented in the presence of 4-AP. These results indicate that the action of 4-AP can be modulated by concurrent neuronal activities.
No takes yet. Share an insight, caveat, or question.
Ohishi et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: