December 15, 1994The Journal of PhysiologyOpen Access

Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

View Full Paper

Ask AI

Bookmark

Population

Xenopus oocytes expressing delayed rectifier Kv1.2 K+ channel

Design

Preclinical

Authors

SRScott N. RussellUniversity of Nevada, Reno NPNelson G. PublicoverDalhousie University PHPádraig HartBelfast Health and Social Care Trust

Discussion

Member takes

Implication

Animal data on 4-AP open-state trapping in Kv1.2; leaves open relevance to human channel-targeted therapies.

Structured PICO

Population

Xenopus oocytes expressing delayed rectifier Kv1.2 K+ channel

Intervention

4-aminopyridine (4-AP) (e.g., 100 microM)

Outcome

Electrophysiological properties of Kv1.2 channel block (rate of onset, steady-state block, mean open time, single-channel current amplitude)surrogate

4-AP blocks the Kv1.2 channel by binding to the open state and becoming trapped upon channel closure, with binding and C-type inactivation being mutually exclusive.

Cite This Study

Russell et al. (1994) studied this question.

synapsesocial.com/papers/6a89cbaa186271ac99334fd2 https://doi.org/10.1113/jphysiol.1994.sp020464

View Full Paper

Ask AI

Bookmark

Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider