Population
Vascular smooth muscle cells enzymatically isolated from the rabbit coronary artery
Comparison
4-aminopyridine at various concentrations vs Control conditions (absence of 4-AP)
Design
Preclinical
Authors
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Animal data on 4-AP IK(V) effects should not guide therapy; extends channel biophysics in vascular models.
4-aminopyridine depolarizes vascular smooth muscle cells by preferentially binding to the closed state of the delayed rectifier K+ channel and shifting its activation curve to more positive potentials.
Remillard et al. (1996) studied this question.
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