Key result
The combination of maximum area stenosis and perivascular fat attenuation index had good diagnostic performance in predicting hemodynamically significant coronary stenosis, comparable with CT-FFR.
Why the study?
The study was conducted to investigate the combined value of CCTA indicators and perivascular FAI in predicting hemodynamically significant coronary artery disease.
Does the combination of maximum area stenosis and perivascular fat attenuation index predict hemodynamically significant coronary artery disease comparably to CT-FFR in patients undergoing CCTA?
Observational
No
Does the combination of maximum area stenosis and perivascular fat attenuation index predict hemodynamically significant coronary artery disease comparably to CT-FFR in patients undergoing CCTA?
Answers are grounded in this paper and cite their sources.
The combination of maximum area stenosis and perivascular fat attenuation index from CCTA offers diagnostic performance comparable to CT-FFR for identifying hemodynamically significant coronary stenosis.
OBJECTIVE: To investigate the combined value of coronary computed tomography angiography (CCTA) indicators and perivascular fat attenuation index (FAI) in predicting hemodynamically significant coronary artery disease. METHODS: We retrospectively analyzed the data of patients undergoing CCTA in Chinese PLA General Hospital from 2017 to 2019, who were also examined for fractional flow reserve (FFR) with invasive coronary angiography within one month before inclusion. The CCTA indicators at the vascular level were measured, including plaque distribution, coronary artery calcification score, lesion length, maximum diameter stenosis, maximum area stenosis (MAS), total plaque burden (TPB), perivascular FAI, and CT-FFR based on machine learning. Lesion-specific hemodynamically significant coronary artery disease was diagnosed for an invasive FFR≤0.8. CONCLUSION: The combination of MAS and perivascular FAI has good diagnostic performance in predicting hemodynamically significant coronary stenosis, which is comparable with that of CT-FFR.
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Shan et al. (2021) conducted an observational in Hemodynamically significant coronary artery disease. Maximum area stenosis combined with perivascular fat attenuation index vs. CT-FFR was evaluated on Hemodynamically significant coronary artery disease (invasive FFR≤0.8) (p==0.076). The combination of maximum area stenosis and perivascular fat attenuation index had good diagnostic performance in predicting hemodynamically significant coronary stenosis, comparable with CT-FFR.
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