Key result
Early initiation of non-pharmacological therapy allowed complete withdrawal of antihypertensive medication in 46.4% of patients, compared to 42.7% in those who delayed initiation by one year.
Why the study?
Does the addition of non-pharmacological therapy and home monitoring allow for the withdrawal of antihypertensive drugs and improve quality of life in patients on antihypertensive medication?
Cohort (n=400)
Yes
Does the addition of non-pharmacological therapy and home monitoring allow for the withdrawal of antihypertensive drugs and improve quality of life in patients on antihypertensive medication?
Absolute Event Rate: 46.4% vs 42.7%
The addition of non-pharmacological therapy and home blood pressure monitoring can facilitate the successful withdrawal of antihypertensive medications and improve patient quality of life.
May support antihypertensive deprescribing with lifestyle support and monitoring; hypothesis-generating and requires RCTs before practice change.
Abstract Åberg H, Tibblin G (Department of Family Medicine. University Hospital, University of Uppsala, Uppsala, Sweden). Addition of non‐pharmacological methods of treatment in patients on antihypertensive drugs: results of previous medication, laboratory tests and life quality. Four hundred patients from eight health centres were recruited for this 2‐year study on the possible replacement of antihypertensive drugs by non‐pharmacological therapy. All the patients were given a device to measure their blood pressure at home and had monthly checks at a health centre. Two hundred patients on antihypertensive drugs (G1) started additional non‐pharmacological therapy after 1 year in the study, while the rest (G2) had used it from the beginning. Antihypertensive drugs were withdrawn according to predetermined criteria. The drop‐out rate was 1.5% each year. Medication was withdrawn completely from 42.7% of G1, and in 21.5% it was withheld for at least 18 months. The corresponding figures for G2 were 46.4% and 25.5% respectively. Most of the medication withdrawal in G1 occurred during the first year, when the group's management consisted solely of blood pressure measurements at home and frequent visits to the health centre. Serum triglycerides decreased on non‐pharmacological treatment in both sexes in both groups. Life quality improved, particularly for the group ( n = 173) that had the drugs withdrawn.
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Åberg et al. (1989) conducted a cohort in Hypertension (n=400). Early non-pharmacological therapy vs. Delayed non-pharmacological therapy (after 1 year) was evaluated on Complete withdrawal of antihypertensive medication. Early initiation of non-pharmacological therapy allowed complete withdrawal of antihypertensive medication in 46.4% of patients, compared to 42.7% in those who delayed initiation by one year.
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