Why the study?
Does withdrawal of antihypertensive drugs lead to the return of elevated blood pressure in previously controlled hypertensive patients?
Population
86 hypertensive patients who received treatment with hydrochlorothiazide, reserpine and hydralazine for two…
Comparison
Withdrawal of active antihypertensive treatment. vs Continued active treatment with…
Design
RCT, assigned double-blind, double-blind
Follow-up
18 months
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Antihypertensive withdrawal risks rapid BP rebound and morbid events; confirms sustained therapy requirement in controlled hypertension.
Does withdrawal of antihypertensive drugs lead to the return of elevated blood pressure in previously controlled hypertensive patients?
Withdrawal of antihypertensive therapy in well-controlled patients leads to a rapid return of elevated blood pressure and increased risk of morbid events in the majority of patients.
A 1975 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: