Key result
Elevated fibrinopeptide A and troponin I levels independently predicted cardiac events at 1 week (OR 4.82 and 9.41, respectively), with FPA also predicting events at 6 months (OR 9.57; P<0.001).
Why the study?
Do elevated levels of fibrinopeptide A, troponin I, myoglobin, and myosin light chain predict early and late ischemic events in patients presenting to the Emergency Department with chest pain?
Cohort (n=247)
Do elevated levels of fibrinopeptide A, troponin I, myoglobin, and myosin light chain predict early and late ischemic events in patients presenting to the Emergency Department with chest pain?
Odds Ratio: 4.82 (95% CI 1.78–13.03)
p-value: p=0.002
Elevated fibrinopeptide A and troponin I levels independently predict early and late ischemic events in patients presenting to the emergency department with chest pain.
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Thrombus and injury markers may aid chest pain risk stratification; leaves open incremental prognostic value in validation studies.
Sonel et al. (2000) conducted a cohort in Chest pain (n=247). Elevated fibrinopeptide A (FPA) and troponin I (TnI) vs. Non-elevated levels was evaluated on Death, myocardial infarction, unstable angina, and coronary revascularization at 1 week (OR 4.82, 95% CI 1.78-13.03, p=0.002). Elevated fibrinopeptide A and troponin I levels independently predicted cardiac events at 1 week (OR 4.82 and 9.41, respectively), with FPA also predicting events at 6 months (OR 9.57; P<0.001).
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