Key result
Selective depression of euglobulin t-PA activity was associated with a 52.9% rate of reinfarction over four years, compared to 0% in patients with marked t-PA activity.
Why the study?
Does selective depression of euglobulin t-PA activity predict reinfarction in patients recovering from a first-time acute myocardial infarction?
Population
29 patients recovering from a first-time acute myocardial infarction (AMI)
Comparison
Selective depression to near zero of euglobulin… vs Marked t-PA activity
Design
Cohort
Follow-up
four years
Authors
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Depressed t-PA activity flags high reinfarction risk post-AMI; challenges standard fibrinolytic assays and extends targeted risk stratification.
Cohort (n=29)
Does selective depression of euglobulin t-PA activity predict reinfarction in patients recovering from a first-time acute myocardial infarction?
Absolute Event Rate: 52.9% vs 0%
Depressed euglobulin t-PA activity identifies a high-risk subgroup for reinfarction among survivors of a first-time acute myocardial infarction.
Gram et al. (1987) conducted a cohort in Acute Myocardial Infarction (AMI) (n=29). Selective depression of euglobulin t-PA activity vs. Marked t-PA activity was evaluated on Reinfarction. Selective depression of euglobulin t-PA activity was associated with a 52.9% rate of reinfarction over four years, compared to 0% in patients with marked t-PA activity.
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