Key result
High-intensity interval training and circuit-resistance training both significantly improved peak oxygen uptake compared to control in patients with heart failure, though neither improved endothelial function.
Why the study?
Exercise training is strongly recommended for heart failure, but high-intensity exercise training modalities remain controversial in this population.
Does high-intensity interval training or progressive high circuit-resistance training improve endothelial function and cardiorespiratory fitness in heart failure patients?
RCT (n=23)
Single-blind
Sealed envelopes in blocks of 3
Yes
Does high-intensity interval training or progressive high circuit-resistance training improve endothelial function and cardiorespiratory fitness in heart failure patients?
Absolute Event Rate: 2.1% vs -0.1%
p-value: p=<0.05
Both high-intensity interval training and progressive high-intensity circuit resistance training improve cardiorespiratory fitness in heart failure patients, though HIIT may offer superior combined benefits on strength and physical performance.
Both HIIT and CRT improve cardiorespiratory fitness in HF without endothelial effects; larger trials needed to confirm HIIT superiority.
INTRODUCTION: Exercise training is strongly recommended as a therapeutic approach to treat individuals with heart failure. High-intensity exercise training modalities still controversial in this population. The study aims to preliminary assess the consequences of high-intensity exercise training modalities, aerobic interval training (HIIT) and progressive high circuit-resistance training (CRT), on primarily endothelial function and cardiorespiratory fitness, and secondly on muscle strength and physical performance in heart failure patients. METHODS: This preliminary multicentric randomized controlled trial comprised 23 heart failure patients, aged 56 ± 10 years old, mainly New York Heart Association classification I and II (%), hemodynamically stable, who compromise at least 36 exercise sessions of a randomly assigned intervention (HIIT, CRT or control group). Endothelial function, cardiopulmonary exercise testing, muscle strength and physical performance were completed at baseline and post-intervention. RESULTS: Although no effects on endothelial function; both HIIT and CRT modalities were able to produce a positive effect on [Formula: see text] peak (HIIT = +2.1±6.5, CRT = +3.0±4.2 and control group = -0.1± 5.3 mL/kg/min, time*group p-value<0,05) and METs (HIIT = +0.6±1.8, CRT = +0.9±1.2 and control group = 0±1.6, time*group p-value<0,05). Only HIIT increased isokinetic torque peak (HIIT = +8.8±55.8, CRT = 0.0±60.7 and control group = 1.6±57.6 Nm) matched p-value<0,05. Regarding the physical performance, the CRT modality reduced chair stand test completion time (HIIT = -0.7±3.1, CRT = -3.3±3.2 and control group = -0.3±2.5 s, matched p-value<0,05 and HIIT improved global physical performance(time*group p<0,05). CONCLUSION: This preliminary study trends to indicate for the first time that high-intensity interval training promotes a jointly superior effect compared to progressive high intensity circuit-resistance training by improving cardiorespiratory fitness, muscular strength, and physical performance. Further research with larger cohort is necessary. CLINICAL TRIAL REGISTRATION NUMBER: ReBEC RBR-668c8v.
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Silva et al. (2021) conducted an RCT in Heart failure (n=23). High-intensity interval training (HIIT) or circuit-resistance training (CRT) vs. Control group was evaluated on Change in peak oxygen uptake (VO2 peak) in mL/kg/min (p=<0.05). High-intensity interval training and circuit-resistance training both significantly improved peak oxygen uptake compared to control in patients with heart failure, though neither improved endothelial function.
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