Key result
Zopiclone impaired more subjects on reaction time and automative behavior tests, whereas ethanol impaired more subjects on impulsivity tests.
Why the study?
Ethanol and zopiclone show vast differences in epidemiological traffic risk, possibly because they impair skills differently, which has been less previously studied.
Does ethanol or zopiclone impair driving-related psychomotor and cognitive skills differently in subjects?
Comparison
Ethanol (50 grams) vs zopiclone 5 mg vs zopiclone 10 mg vs placebo
Design
Randomized cross-over trial
Authors
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Zopiclone and ethanol impair distinct driving skills; extends RCT evidence for differentiated safety counseling.
RCT
cross-over
Does ethanol or zopiclone impair driving-related psychomotor and cognitive skills differently in subjects?
Zopiclone and ethanol exhibit distinct profiles of neurocognitive impairment, with zopiclone affecting reaction time more and ethanol affecting impulsivity more.
Høiseth et al. (2020) reported an RCT. Zopiclone and Ethanol vs. Placebo was evaluated on Performance on computerized psychomotor and cognitive tests (CPT, SOC, CRT). Zopiclone impaired more subjects on reaction time and automative behavior tests, whereas ethanol impaired more subjects on impulsivity tests.
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