Key result
Protonation sites linked to gating of the KcsA K+ channel are located on the intracellular portion of the protein, as demonstrated by channel activation exclusively at low trans-bilayer pH.
Population
KcsA K(+) channel from Streptomyces lividans in planar lipid bilayer membranes
Design
Preclinical
Authors
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Proton activation of KcsA may modulate cardiac K+ gating; leaves open clinical translation.
The study maps the protonation sites responsible for KcsA K+ channel gating to the intracellular portion of the protein.
Heginbotham et al. (1999) studied this question. KcsA K+ channel electrophysiological characterization was evaluated on Channel gating and electrophysiological properties. Protonation sites linked to gating of the KcsA K+ channel are located on the intracellular portion of the protein, as demonstrated by channel activation exclusively at low trans-bilayer pH.
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