Key result
Lu-ECAM-1 is an endothelial cell surface molecule that shares 88% sequence identity with a tracheal calcium-dependent chloride channel, suggesting it functions as an endothelial chloride channel.
Population
Bovine aortic endothelial cells (BAEC) and human embryonic kidney 293 cells
Design
Preclinical
Authors
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May link endothelial adhesion to chloride conductance in metastasis; leaves open functional validation in vivo.
The study reveals that Lu-ECAM-1, an endothelial cell adhesion molecule involved in metastasis, is homologous to a calcium-dependent chloride channel.
Elble et al. (1997) studied this question. Lu-ECAM-1 is an endothelial cell surface molecule that shares 88% sequence identity with a tracheal calcium-dependent chloride channel, suggesting it functions as an endothelial chloride channel.
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