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Shows improved muscle oxidative properties and performance in limb girdle muscular dystrophy, suggesting a potential therapeutic approach.
, including improved oxidative properties, increased slow fiber size, and enhanced exercise performance. AMBMP also activated CaMKIIβ signaling, but it did not alter other pathways known to be associated with muscle growth. Thus, AMBMP treatment activates CaMKII and metabolically reprograms skeletal muscle toward a slow muscle phenotype. These proof-of-concept studies lend support for an approach to the development of therapeutics for LGMDR1.
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Liu et al. (2020) studied this question.
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