Key result
Marfan syndrome in children was associated with impaired left ventricular early diastolic function, including slower LV peak diameter lengthening rates (106 vs 132 mm/s, P=0.004).
Case-Control (n=44)
Absolute Event Rate: 106% vs 132%
p-value: p=0.004
Children with Marfan syndrome exhibit impaired left ventricular early diastolic function (relaxation) even in the absence of significant valve disease.
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Diastolic relaxation impairment without systolic changes suggests primary myocardial involvement in pediatric Marfan; hypothesis-generating, needs prospective confirmation before clinical adoption.
Savolainen et al. (1994) conducted a case-control in Marfan syndrome (n=44). Marfan syndrome vs. Age-matched healthy children was evaluated on LV peak diameter lengthening rate (mm/s) (p=0.004). Marfan syndrome in children was associated with impaired left ventricular early diastolic function, including slower LV peak diameter lengthening rates (106 vs 132 mm/s, P=0.004).
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