Key result
Patients with Marfan syndrome and rapid aortic root dilatation had significantly impaired left ventricular diastolic filling, including prolonged deceleration time (199 vs 172 ms, p=0.005).
Cohort (n=27)
No
Absolute Event Rate: 199% vs 172%
p-value: p=0.005
Disturbed diastolic filling of the left ventricle may serve as an early, non-invasive marker of fast aortic root dilatation in patients with Marfan syndrome.
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Impaired LV diastolic filling may flag rapid aortic dilatation in Marfan syndrome; leaves open prospective validation before clinical adoption.
Lazarević et al. (2004) conducted a cohort in Marfan syndrome (n=27). Rapid aortic root dilatation (>3% per year) vs. Slow aortic root dilatation (<3% per year) was evaluated on Deceleration time (DT) of the E wave (p=0.005). Patients with Marfan syndrome and rapid aortic root dilatation had significantly impaired left ventricular diastolic filling, including prolonged deceleration time (199 vs 172 ms, p=0.005).
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