Key result
Aortic root dilation typical of Marfan syndrome alters the evolution of vorticity shed from valve leaflets, redirecting the systolic jet and modifying residual diastolic flow.
Why the study?
Does aortic root dilation in Marfan syndrome alter fluid dynamics and systolic jet orientation in an in-vitro model?
Does aortic root dilation in Marfan syndrome alter fluid dynamics and systolic jet orientation in an in-vitro model?
In-vitro modeling demonstrates that aortic root dilation in Marfan syndrome significantly alters fluid dynamics, redirecting the systolic jet and potentially increasing the risk of localized wall damage.
Answers are grounded in this paper and cite their sources.
Alters jet dynamics in Marfan model; hypothesis-generating and leaves open clinical relevance pending in-vivo studies.
Aortic root dilation and propensity to dissection are typical manifestations of the Marfan Syndrome (MS), a genetic defect leading to the degeneration of the elastic fibres. Dilation affects the structure of the flow and, in turn, altered flow may play a role in vessel dilation, generation of aneurysms, and dissection. The aim of the present work is the investigation in-vitro of the fluid dynamic modifications occurring as a consequence of the morphological changes typically induced in the aortic root by MS. A mock-loop reproducing the left ventricle outflow tract and the aortic root was used to measure time resolved velocity maps on a longitudinal symmetry plane of the aortic root. Two dilated model aortas, designed to resemble morphological characteristics typically observed in MS patients, have been compared to a reference, healthy geometry. The aortic model was designed to quantitatively reproduce the change of aortic distensibility caused by MS. Results demonstrate that vorticity released from the valve leaflets, and possibly accumulating in the root, plays a fundamental role in redirecting the systolic jet issued from the aortic valve. The altered systolic flow also determines a different residual flow during the diastole.
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Querzoli et al. (2014) studied Marfan syndrome (n=3). Dilated aortic root models (M1 and M2) vs. Healthy aortic root model (H) was evaluated on Fluid dynamic modifications (velocity and vorticity patterns). Aortic root dilation typical of Marfan syndrome alters the evolution of vorticity shed from valve leaflets, redirecting the systolic jet and modifying residual diastolic flow.
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