Why the study?
Does immunization with the ADP/ATP carrier induce autoantibodies that penetrate myocardial cells and disturb energy metabolism in guinea pigs?
Population
Guinea pigs immunized with the isolated ADP/ATP carrier
Comparison
Immunization with the isolated ADP/ATP carrier vs Controls performing equal external heart work
Design
Preclinical
Key result
Immunization with the ADP/ATP carrier in guinea pigs generated autoantibodies that penetrated myocardial cells, decreasing cytosolic ATP and increasing mitochondrial ATP versus controls.
Authors
Loading...
May implicate mitochondrial autoimmunity in myocarditis and DCM pathogenesis; hypothesis-generating pending clinical validation.
Does immunization with the ADP/ATP carrier induce autoantibodies that penetrate myocardial cells and disturb energy metabolism in guinea pigs?
Autoantibodies to the ADP/ATP carrier can penetrate living myocardial cells and disrupt energy metabolism, providing a mechanistic basis for their role in myocarditis and dilated cardiomyopathy.
Schulze et al. (1989) studied Myocarditis and dilated cardiomyopathy. Immunization with isolated ADP/ATP carrier vs. Controls performing equal external heart work was evaluated on Cytosolic and intramitochondrial distribution of adenine nucleotides (ATP/ADP ratio). Immunization with the ADP/ATP carrier in guinea pigs generated autoantibodies that penetrated myocardial cells, decreasing cytosolic ATP and increasing mitochondrial ATP versus controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: