Why the study?
Do antibodies against the ADP/ATP carrier influence nucleotide transport and energy metabolism in myocardial cells?
Do antibodies against the ADP/ATP carrier influence nucleotide transport and energy metabolism in myocardial cells?
Auto-antibodies against the ADP/ATP carrier alter myocardial energy metabolism, suggesting a pathophysiological role in myocarditis and dilated cardiomyopathy.
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Autoantibodies may impair myocardial energy metabolism; hypothesis-generating for their role in myocarditis and dilated cardiomyopathy.
After immunization of guinea pigs with purified ADP/ATP carrier, intracellular depositions of immunoglobulins in the myocardium were found. In vitro, these antibodies induced an inhibition of nucleotide transport. In vivo, in the hearts of the immunized animals, a shift of the cytosolic and mitochondrial phosphorylation potential of ATP was observed. These findings suggest that antibodies against the ADP/ATP carrier influence nucleotide transport and energy metabolism not only in vitro but also in vivo. Both the experimental and clinical results point to a possible pathophysiological significance of auto-antibodies against the ADP/ATP carrier in myocarditis and dilated cardiomyopathy.
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Schulze et al. (1987) studied this question.
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