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November 2, 1987European Heart Journal

Antibodies against the ADP/ATP carrier induced an inhibition of nucleotide transport in vitro and a shift of the cytosolic and mitochondrial phosphorylation potential of ATP in vivo.

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Why the study?

Do antibodies against the ADP/ATP carrier influence nucleotide transport and energy metabolism in myocardial cells?

Population

Guinea pigs

Design

Preclinical

Authors

KSK. SchulzeHSHeinz‐Peter Schultheiß

Discussion

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Overview

Autoantibodies may impair myocardial energy metabolism; hypothesis-generating for their role in myocarditis and dilated cardiomyopathy.

Structured PICO

Do antibodies against the ADP/ATP carrier influence nucleotide transport and energy metabolism in myocardial cells?

P
Population
Guinea pigs
I
Intervention
Immunization with purified ADP/ATP carrier to generate antibodies
O
Outcome
Shift of the cytosolic and mitochondrial phosphorylation potential of ATP (in vivo) and inhibition of nucleotide transport (in vitro)surrogate

Auto-antibodies against the ADP/ATP carrier alter myocardial energy metabolism, suggesting a pathophysiological role in myocarditis and dilated cardiomyopathy.

Cite This Study

Schulze et al. (1987) studied this question.

synapsesocial.com/papers/6a702e22ac440176ef28d37ehttps://doi.org/10.1093/eurheartj/8.suppl_j.211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo.1989 · 138 citations
  2. 2Antibodies to ADP-ATP carrier--an autoantigen in myocarditis and dilated cardiomyopathy--impair cardiac function.1990 · 196 citations
  3. 3Antibody-Mediated Imbalance of Myocardial Energy Metabolism1995 · 47 citations
  4. 4The mitochondrium as antigen in inflammatory heart disease1987 · 40 citations
  5. 5Disturbance of myocardial energy metabolism in experimental virus myocarditis by antibodies against the adenine nucleotide translocator1999 · 51 citations