Population
Guinea pigs and A-strain mice
Design
Preclinical
Authors
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Animal data link carrier autoantibodies to impaired energetics and function; leaves open relevance to human viral myocarditis.
Viral infection or immunization with ADP/ATP carrier protein induces carrier-inactivating autoantibodies that impair myocardial energy metabolism and cardiac function, suggesting an autoimmune mechanism in viral heart disease.
Schulze et al. (1995) studied this question.
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