What question did this study set out to answer?

To explore how left ventricular geometry affects brain natriuretic peptide levels in elderly individuals.

January 1, 2000Gerontology

Relationship between Left Ventricular Geometry and Brain Natriuretic Peptide Levels in Elderly Subjects

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Left ventricular hypertrophy. Intervention: Left ventricular hypertrophy (eccentric or concentric) vs. Normal geometry and concentric remodeling. Primary outcome: Plasma BNP levels (p=<0.05).

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Key result

Left ventricular eccentric and concentric hypertrophy were associated with higher plasma BNP levels, correlating with relative (r=-0.474) and posterior wall thickness (r=0.396, p<0.05).

Population

Elderly patients with or without left ventricular hypertrophy, classified into normal geometry, concentric…

Design

Cross-sectional

Authors

HSHarumi SayamaKyoto Medical Center YNYasuyuki NakamuraYamashina Institute for Ornithology NSNoboru SaitoOkayama University

Discussion

Member takes

Implication

BNP may flag hypertrophy burden in elderly assessment; leaves open prognostic utility pending longitudinal data.

Key Points

To explore how left ventricular geometry affects brain natriuretic peptide levels in elderly individuals.
Measured plasma BNP levels in elderly subjects with various left ventricular geometries.
Classified patients into four groups: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy.
Correlated plasma BNP levels with echocardiographic measurements and performed regression analysis.
Plasma BNP levels were significantly higher in the eccentric hypertrophy and concentric hypertrophy groups compared to normal geometry and concentric remodeling.
A strong correlation was found between plasma BNP levels and relative wall thickness in eccentric hypertrophy (r = -0.474, p < 0.05).
Age and left ventricular mass index were significant independent predictors of plasma BNP levels.

Study Design

Type

Observational

Structured PICO

Population

Elderly patients with or without left ventricular hypertrophy, classified into 4 groups based on echocardiographic geometry.

Outcome

Plasma brain natriuretic peptide (BNP) levelssurrogate

Main Result

p-value: p=<0.05

Aging and the extent of cardiac hypertrophy (LV mass index) are significant independent contributors to elevated plasma BNP levels in elderly subjects.

Cite This Study

Sayama et al. (2000) conducted an observational in Left ventricular hypertrophy. Left ventricular hypertrophy (eccentric or concentric) vs. Normal geometry and concentric remodeling was evaluated on Plasma BNP levels (p=<0.05). Left ventricular eccentric and concentric hypertrophy were associated with higher plasma BNP levels, correlating with relative (r=-0.474) and posterior wall thickness (r=0.396, p<0.05).

synapsesocial.com/papers/6a65798866784dc805f71bbd https://doi.org/10.1159/000022137

Topics

Echocardiography

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Relationship between Left Ventricular Geometry and Brain Natriuretic Peptide Levels in Elderly Subjects

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Relationship between Left Ventricular Geometry and Brain Natriuretic Peptide Levels in Elderly Subjects

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider