Key result
A 1-year lifestyle intervention in overweight-obese patients with essential hypertension improved RRI, but HOMA-IR remained significantly higher compared to controls.
Why the study?
Does a 1-year lifestyle intervention improve insulin resistance and renal artery stiffness in overweight-obese patients with essential hypertension?
Cohort (n=315)
Does a 1-year lifestyle intervention improve insulin resistance and renal artery stiffness in overweight-obese patients with essential hypertension?
A 1-year lifestyle intervention improves renal resistive index but fails to normalize insulin resistance in overweight-obese patients with essential hypertension, suggesting the need for more intensive dietary strategies.
Answers are grounded in this paper and cite their sources.
Persistent abnormal HOMA-IR after lifestyle intervention in obese hypertensives; leaves open whether adjunctive therapies are required.
The study investigates lifestyle and effective anti-hypertensive intervention in overweight-obese patients can influence insulin-resistance (HOMA-IR) and US Renal-Resistive-Index (RRI). After a 1-year interventional program (including a personalized Mediterranean diet, physical activity increase, smoking withdrawal counseling), 156 Essential Hypertension (EH) patients still have abnormal HOMA-IR, significantly higher in comparison to 159 control group patients. Body mass index (BMI) and cholesterol-high-density-lipoprotein improvement are the best predictors of a HOMA-IR decrease; RRI improves in EH according to lifestyle interventions, but no predictor to RRI is identified. Persistence of IR can be tentatively assumed as a steady sign, persistent also after extended lifestyle intervention in EH, further warranting more intensive dietary interventions.
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Trovato et al. (2010) conducted a cohort in Essential Hypertension (n=315). Lifestyle intervention program (Mediterranean diet, physical activity, smoking withdrawal) vs. Control group was evaluated on Insulin-resistance (HOMA-IR) and US Renal-Resistive-Index (RRI). A 1-year lifestyle intervention in overweight-obese patients with essential hypertension improved RRI, but HOMA-IR remained significantly higher compared to controls.
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