Key result
Poliovirus-induced degradation of the interferon-induced P68 protein kinase requires an RNA component and divalent cations, with degradation sites localized to dsRNA-binding domains.
Population
In vitro degradation assay and poliovirus-infected cells
Design
Preclinical
Authors
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May enable poliovirus protein synthesis; leaves open extension to other viruses or therapies.
Poliovirus degrades the interferon-induced P68 protein kinase via a mechanism requiring RNA and divalent cations, targeting the amino terminus dsRNA-binding domains.
Black et al. (1993) studied Poliovirus infection. Poliovirus infection was evaluated on Mechanism of P68 degradation. Poliovirus-induced degradation of the interferon-induced P68 protein kinase requires an RNA component and divalent cations, with degradation sites localized to dsRNA-binding domains.
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