Key result
Specific regions of actin subdomain 1 were implicated in the interaction with fimbrin, demonstrating functional redundancy between different surfaces of actin in budding yeast.
Population
Budding yeast with 21 actin mutations
Comparison
Actin mutations (including act1-120 actin) vs Wild-type actin gene and null alleles of SAC6…
Design
Preclinical
Authors
Loading...
Yeast genetic screen maps actin subdomain 1 residues for ABP interactions; leaves open conservation in mammalian cardiovascular models.
An in vivo strategy in budding yeast identified specific amino acids of actin required for functional interactions with actin-binding proteins like fimbrin.
Holtzman et al. (1994) studied this question. Actin mutations vs. Wild-type actin was evaluated on Functional interactions with actin-binding proteins. Specific regions of actin subdomain 1 were implicated in the interaction with fimbrin, demonstrating functional redundancy between different surfaces of actin in budding yeast.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: