Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin.

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Population

Yeast actin mutations (eight different act1 mutations) and Sac6p (homologous to vertebrate fimbrin)

Design

Preclinical

Authors

Discussion

Suggests fimbrin-actin interface residues in yeast; leaves open validation in mammalian cardiomyocytes and functional relevance.

Population

Yeast actin mutations (eight different act1 mutations) and Sac6p (homologous to vertebrate fimbrin)

Intervention

Sequence analysis and biochemical analysis of mutant actins

Outcome

Identification of the region on actin that interacts with Sac6p

The study identifies a likely site of interaction of fimbrin on actin by analyzing yeast actin mutations.

Honts et al. (1994) studied this question.

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