Key result
In anephric rats, chronic administration of ANG II or losartan markedly inhibited the nephrectomy-induced rise in aldosterone concentrations (from 465 ng/100 ml in vehicle to 177 and 199 ng/100 ml).
Why the study?
Does Angiotensin II or losartan inhibit aldosterone production in anephric rats?
Population
Anephric rats (subjected to bilateral nephrectomy and hemodialysis)
Comparison
Angiotensin II or losartan vs Vehicle infusion
Design
Preclinical
Follow-up
55 hours after nephrectomy
Authors
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Chronic ANG II infusion blunts post-nephrectomy aldosterone rise in rats; leaves open net effects on human aldosterone regulation.
Does Angiotensin II or losartan inhibit aldosterone production in anephric rats?
Absolute Event Rate: 177% vs 465%
Aldosterone production after nephrectomy is regulated by an intraadrenal renin-angiotensin system that is suppressed by circulating angiotensin and inhibited by losartan.
Peters et al. (1999) studied Anephric rats (nephrectomy-induced rise of aldosterone). Angiotensin II and Losartan vs. Vehicle infused was evaluated on Aldosterone concentrations. In anephric rats, chronic administration of ANG II or losartan markedly inhibited the nephrectomy-induced rise in aldosterone concentrations (from 465 ng/100 ml in vehicle to 177 and 199 ng/100 ml).
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