Key result
In a case series of 21 LVAD recipients, angiotensin receptor-neprilysin inhibitor initiation was safe, feasible, and improved blood pressure management, functional capacity, and diuretic requirements.
Why the study?
ARNIs benefit functional capacity and longevity in HFrEF, but remain underutilized and unstudied in LVAD recipients despite their underlying HFrEF.
Does ARNI utilization improve blood pressure and heart failure control in LVAD patients?
Observational (n=21)
Does ARNI utilization improve blood pressure and heart failure control in LVAD patients?
ARNIs appear safe and feasible in LVAD recipients, offering potential short-term benefits for blood pressure control, functional capacity, and diuretic requirements.
Angiotensin receptor-neprilysin inhibitors (ARNIs) greatly benefit functional capacity and longevity in heart failure with reduced ejection fraction (HFrEF). Angiotensin receptor-neprilysin inhibitors remain underutilized and unstudied, however, in left ventricular assist device (LVAD) recipients, in spite of their underlying HFrEF. In this case series, we studied the feasibility and short-term efficacy of ARNI utilization in 21 LVAD patients. Angiotensin receptor-neprilysin inhibitor initiation was successful in most, resulting in significant consolidation of blood pressure (BP) medical management and marked improvements in both functional capacity and diuretic requirements. Angiotensin receptor-neprilysin inhibitors are safe, feasible, and within a short timeframe benefit BP and heart failure control in LVAD recipients.
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Goldberg et al. (2021) conducted an observational in Left ventricular assist device (LVAD) recipients with HFrEF (n=21). Angiotensin receptor-neprilysin inhibitors (ARNIs) was evaluated on Feasibility and short-term efficacy (blood pressure management, functional capacity, and diuretic requirements). In a case series of 21 LVAD recipients, angiotensin receptor-neprilysin inhibitor initiation was safe, feasible, and improved blood pressure management, functional capacity, and diuretic requirements.
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