Key result
Prothrombin complex concentrate resulted in a lower posttreatment INR (1.32 vs 2.30) and significantly improved complete reversal and reversal time compared to FFP and vitamin K (p < 0.001).
Why the study?
Does prothrombin complex concentrate improve complete reversal and reversal time in anticoagulated patients with intracranial haemorrhage requiring urgent neurosurgical intervention compared to fresh frozen plasma and vitamin K?
Cohort
No
Does prothrombin complex concentrate improve complete reversal and reversal time in anticoagulated patients with intracranial haemorrhage requiring urgent neurosurgical intervention compared to fresh frozen plasma and vitamin K?
Absolute Event Rate: 1.32% vs 2.3%
p-value: p=< 0.001
Prothrombin complex concentrate provides rapid and effective reversal of oral anticoagulation in life-threatening neurosurgical emergencies compared to fresh frozen plasma and vitamin K.
No takes yet. Share an insight, caveat, or question.
Pilot data on reversal in anticoagulated neurosurgical ICH may guide local practice; leaves open need for confirmatory trials.
G. Dolan M. Cartmill (2000) conducted a cohort in Intracranial haemorrhage requiring urgent correction of anticoagulation. Prothrombin complex concentrate vs. Fresh frozen plasma and vitamin K was evaluated on Posttreatment International Normalised Ratio (INR) (p=< 0.001). Prothrombin complex concentrate resulted in a lower posttreatment INR (1.32 vs 2.30) and significantly improved complete reversal and reversal time compared to FFP and vitamin K (p < 0.001).
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