What question did this study set out to answer?

This research aims to investigate the use of genetically engineered myoblasts for delivering recombinant proteins systemically.

December 6, 1991Science

Systemic Delivery of Recombinant Proteins by Genetically Modified Myoblasts

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Randomized trial examines the delivery of recombinant proteins using modified myoblasts, suggesting a potential treatment for inherited diseases.

This research aims to investigate the use of genetically engineered myoblasts for delivering recombinant proteins systemically.
Produced stable transfectants of murine C2C12 myoblasts synthesizing human growth hormone.
Injected hGH-transfected myoblasts into mice to evaluate protein levels over time.
Conducted histological examinations of injected muscle tissues.
Mice receiving hGH-transfected myoblasts showed significant hGH levels in muscle and serum for at least 3 weeks.
Injected myoblasts fused to form multinucleated myotubes, indicating successful integration.
Demonstrated feasibility of genetically engineered myoblasts for stable protein delivery.

Barr et al. (1991) studied this question.

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Randomized trial examines the delivery of recombinant proteins using modified myoblasts, suggesting a potential treatment for inherited diseases.