Key result
Adding salicylate to enalapril in patients with heart failure had no significant de-unloading effect during the day and provided no further reduction in thromboxane A2 synthesis.
Why the study?
Does adding salicylate to enalapril affect ventricular unloading and prostanoid synthesis in patients with heart failure due to myocardial infarction?
Population
20 patients with heart failure due to myocardial infarction and an ejection fraction less than 0.40.
Comparison
Enalapril plus salicylate once daily vs Enalapril plus placebo once daily
Design
RCT, Double blind
Follow-up
3 days in hospital followed by 2 months outside hospital
Authors
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Low risk salicylate attenuates enalapril unloading benefit in HF; supports safe co-use with ACEIs in CAD patients.
RCT (n=20)
Double-blind
No
Does adding salicylate to enalapril affect ventricular unloading and prostanoid synthesis in patients with heart failure due to myocardial infarction?
Adding salicylate to enalapril in heart failure patients does not substantially reduce ventricular unloading but may be less effective than expected in reducing reinfarction risk due to enalapril's existing suppression of thromboxane A2 synthesis.
Baur et al. (1995) conducted an RCT in Heart failure due to coronary artery disease (n=20). Salicylate vs. Placebo (both groups on background enalapril) was evaluated on Blood pressure, plasma converting enzyme activity; plasma angiotensin II and noradrenaline concentrations; excretion of metabolites of renal and systemic prostanoids. Adding salicylate to enalapril in patients with heart failure had no significant de-unloading effect during the day and provided no further reduction in thromboxane A2 synthesis.
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