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July 26, 2026Journal of Clinical MedicineOpen Access

Triple Network Neuroplasticity and Perinatal Mood Symptoms from Preconception to Postpartum: A Pilot Study

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Authors

SFSharon FlorentinTel Aviv UniversityABAtira BickHebrew University of JerusalemMAMoriah AzoulayHebrew University of Jerusalem

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Implication

Pilot study reveals brain connectivity changes related to mood symptoms from preconception to postpartum.

Key Points

  • This study aims to explore the connections between brain networks and mood symptoms during the perinatal period.
  • Pilot study with 22 women followed from preconception to postpartum.
  • Participants completed anxiety and depression questionnaires and underwent fMRI scans at both time points.
  • Average connectivity of the fronto-parietal network, default-mode network, and salience network was assessed.
  • Increased resting-state functional connectivity from the left anterior prefrontal cortex to the default-mode network from preconception to postpartum.
  • Decreased connectivity from the right ventral posterior cingulate cortex to the fronto-parietal network over the same period.
  • Positive association found between right supplementary motor area connectivity to the fronto-parietal network at preconception and postpartum depression scores (p < 0.05).

Cite This Study

Florentin et al. (2026) studied this question.

synapsesocial.com/papers/6a65a306d3aea3239cd76499https://doi.org/10.3390/jcm15155766
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