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July 26, 2026BMC PsychiatryOpen Access

Risperidone for children with attention-deficit/hyperactivity disorder and severe behavioral dysregulation: a randomized placebo-controlled assessor-blinded trial

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Authors

EAEzatollah AbbasiAAAlireza AbdiRERana Eskandari

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Overview

Randomized trial evaluates risperidone's impact on ADHD symptoms in children, indicating potential benefits with monitoring.

Key Points

  • This study aims to evaluate the efficacy and safety of risperidone in children with ADHD and severe behavioral dysregulation.
  • 48-week randomized, placebo-controlled, assessor-blinded trial
  • Children aged 3–12 with moderate-to-severe ADHD allocated to risperidone (n=48) or placebo (n=46)
  • Primary outcome was change in ADHD-RS-IV scores from baseline to week 48.
  • Risperidone reduced ADHD-RS-IV scores more than placebo (week 48: 15.63 vs. 26.47, p<0.001)
  • Parent-rated Conners’ scores improved significantly in the risperidone group (week 48: 16.94 vs. 28.42, p<0.001)
  • Higher clinical response rate with risperidone (70.8% vs. 21.7%; p<0.001).

Cite This Study

Abbasi et al. (2026) studied this question.

synapsesocial.com/papers/6a65a337d3aea3239cd767cahttps://doi.org/10.1186/s12888-026-08433-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of risperidone for attention deficit hyperactivity disorder and disruptive behaviour disorders: a systematic review and meta-analysis2026
  2. 2Efficacy of Oral Methylphenidate and Risperidone in Treatment of Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial2024
  3. 3Evaluation of Metabolic Changes and Treatment Outcomes Associated with Risperidone in Paediatric Patients2025
  4. 4Risperidone plasma concentrations and side effects/effectiveness in children and adolescents with autism spectrum disorder2024
  5. 5A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia1999 · 620 citations